Biomedical Flows Simulation & Multiscale Modeling Lab (BioSiMM Lab)

Computational methods are emerging as relevant tools for diagnosing, treating, and quantifying disease progression. However, the translation of these computational methods to the clinic is not yet a reality. The BioSiMM Lab focuses on patient-specific multi-scale modeling and computational fluid dynamics. Our goal is to leverage computational simulations to provide improved patient-specific risk-stratification metrics and enable the design of personalized therapies at a reasonable computational cost. The group's research areas include thrombosis, vascular and microvascular blood flow modeling, transport and drug delivery, and medical device development, emphasizing investigating sex differences in cardiovascular disease.


Headshot of Gutiérrez

Noelia Grande Gutiérrez

Assistant Professor, Mechanical Engineering

Courtesy appointment, Biomedical Engineering

Noelia Grande Gutiérrez joined the Department of Mechanical Engineering at Carnegie Mellon University in Fall 2021. Her research group works at the intersection of computational engineering and medicine. The BioSiMM Lab strives to provide new insight into health and disease towards more personalized patient care using computational modeling.

4206 Wean Hall
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Noelia Grande Gutiérrez


Selected Publications


N. Grande Gutiérrez, T. Sinno, S.L. Diamond. “A 1D-3D hybrid model of patient-specific coronary hemodynamics.Cardiovascular Engineering and Technology (2021)

N. Grande Gutiérrez, M. Alber, A.M. Kahn, Jane C. Burns, M. Mathew, Brian W. McCrindle, A.L. Marsden. ”Computational modeling of blood component transport related to coronary artery thrombosis in Kawasaki disease patients.” PLoS computational biology, Vol. 17 (9) (2021)

N. Grande Gutiérrez, K. N. Shankar, T. Sinno, S.L. Diamond. “Thrombosis and Hemodynamics: external and intrathrombus gradients.Current Opinion in Biomedical Engineering, Vol. 19 (2021)


N. Grande Gutiérrez, M. Mathew, B. McCrindle, J.S. Tran, A.M. Kahn, J.C. Burns, A.L. Marsden. “Hemodynamic variables in aneurysms are associated with thrombotic risk in children with Kawasaki disease.International Journal of Cardiology, Vol. 281 (2019)


N. Grande Gutiérrez, A. Kahn, J.C. Burns, A.L. Marsden. “Computational blood flow simulations in Kawasaki disease patients: Insight into coronary artery aneurysm hemodynamics.Global cardiology science & practice, (3) (2017)

N. Grande Gutiérrez, O. Shirinsky, N.V. Gagarina, G.A. Lyskina, R. Fukazawa, S. Ogawa, J.C. Burns, A.L. Marsden, A.M. Kahn. “Assessment of coronary artery aneurysms caused by Kawasaki disease using transluminal attenuation gradient analysis of computerized tomography angiograms.American Journal of Cardiology, Vol.120 (4) (2017)


B.R. Macias, J.H.K. Liu, N. Grande Gutiérrez, A.R. Hargens. “Intraocular and intracranial pressures during head-down tilt with lower body negative pressure.Aviation, Space, and Environmental Medicine, Vol. 86 (1) (2015)