Associate Professor, Materials Science & Engineering and Biomedical Engineering
Courtesy Appointment, Mechanical Engineering
Carnegie Mellon University
Pittsburgh, PA 15213-3890
Office: Scott Hall - 4N109
Phone: (412) 268-4897
Dr. Feinberg earned a BS in Materials Science and Engineering from Cornell University in 1999, followed by a Masters (2002) and Ph.D. (2004) in Biomedical Engineering from the University of Florida, where his doctoral work was focused on engineering cell-material interactions to prevent and enhance adhesion. He was then a Postdoctoral Fellow at Harvard University from 2005 to 2010, where he developed new biomaterials and cardiac tissue engineering strategies for 3-dimensional myocardial regeneration, with a focus on stem cell-based approaches. Dr. Feinberg joined CMU in the fall of 2010 as an Assistant Professor with joint appointments in Biomedical Engineering and Materials Science and Engineering.
Ph.D., Biomedical Engineering from the University of Florida, 2004
We develop materials-based, regenerative strategies with the goal of engineering the self-organization and self-assembly of various cell types into tissue structures and understanding the emergence of higher-order function in neuromuscular and cardiovascular systems. Our specific focus is on the interaction of cells and tissues with engineered materials and determining how cells sense, respond and modulate their environment. This is a problem that spans from the molecular (nano) to the tissue (macro) level where we try to elucidate how biochemical, electrical and mechanical signals are propagated across spatiotemporal scales.
Current efforts are focused on the following areas.
- 3-dimensional nano/micro structured tissue engineering scaffolds using protein-based materials
- Engineered skeletal muscle soft robotic devices and bioprosthetics
- Stem cell differentiation and engineered morphogenesis of cardiovascular tissues
P. W. Alford*, A. W. Feinberg*, S. P. Sheehy and K. K. Parker, “Biohybrid Thin Films for Measuring Contractility in Engineered Cardiovascular Muscle,” Biomaterials, Vol. 31, no. 13, 2010, pp 3613-3621. (*co-first authors)
I. J. Domian, M. Chiravuri, P. van der, Meer, A. W. Feinberg, X. Shi, Y. Shao, S. M. Wu, K. K. Parker, K. R. Chien, “Generation of Functional Ventricular Heart Muscle from Mouse Ventricular Progenitor Cells,” Science, Vol. 326 (5951), 2009, pp 426 - 429.
A. W. Feinberg, J. F. Schumacher and A. B. Brennan, “Engineering High-Density Endothelial Cell Monolayers on Soft Substrates,” Acta Biomaterialia, Vol. 5 (6), 2009, pp 2013 – 2024.
A. W. Feinberg, W. Wilkerson, C. A. Seegert, A. L. Gibson, L. H. Wilson and A. B. Brennan, “Systematic Variation of Microtopography, Surface Chemistry and Elastic Modulus and the State Dependent Effect on Endothelial Cell Alignment,” Journal of Biomedical Materials Research: Part A, 86A (2), 2008, pp 522-534.
A. W. Feinberg, A. Feigel, S. S. Shevkopylas, S. P. Sheehy, G. M. Whitesides and K. K. Parker, “Muscular Thin Films for Building Actuators and Powering Devices,” Science, Vol. 317 (5843), 2007, pp 1366 – 1370.